Factor V: a combination of Dr Jekyll and Mr Hyde.
نویسندگان
چکیده
The desirable process of hemostasis and the undesirable phenomena of thromboses are unequivocally consequences of the generation of thrombin by the prothrombinase complex. This stoichiometric complex of factor Xa and factor Va assembled on a platelet membrane converts membrane-bound prothrombin into its active products by 2 sequential peptide-bond cleavages. The functionality and durability of the prothrombinase complex is subject to multiple regulatory processes that may enhance or eliminate its function. Factor Va, an essential component of prothrombinase, is both produced and destroyed by proteolytic events. The absence or dysfunction of factor Va leads to hemorrhagic disease, whereas excessive longevity of the active species is associated with thrombosis. Factor V is thus required for a good outcome (Dr Jekyll) but also is a potential source of disaster (Mr Hyde). In this review, we summarize the current state of knowledge with respect to the good and the bad aspects of factor V functionality and durability.
منابع مشابه
Dr. Jekyll or Mr. Hyde: Information Security in the Ecosystem of Healthcare
“Jekyll and Hyde” embodies how information security affects today’s healthcare ecosystem. When security works, it promotes patient health and a smooth operating ecosystem (Dr. Jekyll); when it doesn’t, privacy and health compromises can occur (Mr. Hyde). In this paper, we argue that unusable security triggers this split personality and in doing so, compromises the heart of the healthcare ecosys...
متن کاملLublin Studies in Modern Languages and Literature
The paper engages with Stevenson’s novel The Strange Case of Dr Jekyll and Mr Hyde from the perspective of essential duality embedded in every one’s nature: it explicates the entangling nature of binaries and the aesthetics of non-disjunction of the binary self/Other as embodied in the figures of Dr Jekyll and Mr Hyde respectively. By the novel’s end, the two aspects, the Jekyllean and the Hyde...
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عنوان ژورنال:
- Blood
دوره 101 1 شماره
صفحات -
تاریخ انتشار 2003